Alprazolam (Xanax) 0.5 mg OP
- Peak: 1-2 hrs
- Half-life: 6-12hrs
- Use: anxiolytic
Lorazepam (Ativan) 1 mg PO
- Peak: 2 hrs
- Half-life: 12 hrs
- Use: anxiolytic, anticonvulsant, hypnotic
Clonazepam (Klonopin) 0.5 mg PO
- Peak: 1-4 hrs
- Half-life: 30-40 hrs
- Use: anxiolytic, anticonvulsant
Temazepam (Restoril) 10 mg PO
- Peak: 1-2 hrs
- Half-life: 8-10 hrs
- Use: anxiolytic, hypnotic
Diazepam (valium) 5 mg PO
- Peak: 1-1.5 hrs
- Half-life: 48-100 hrs (active metabolite up to 200 hrs)
- Use: anxiolytic, muscle relaxant, anticonvulsant
Chlordiazepoxide (Librium) 25 mg PO
- Peak: 2- 4 hrs
- Half-life: 24-48 hrs. (active metabolite up to 200 hrs)
- Use: anxiolytic, alcohol withdrawal
Hypnotics are used to induce sleep
There is considerable variability in the reported ranges for peak concentration and half-life. Wherever possible, data is extracted from package inserts.
Long acting benzodiazepines have active metabolites.
Dosing listed above is for equivalence in ORAL administration only.
Careful consideration should be given to patient age, liver function, and co-ingestion of metabolic inhibitors or other non-benzodiazepine sedative medications (opioids, alcohol, etc).
Benzodiazepines: How They Work And How To Withdraw (aka The Ashton Manual), Chapter : The Benzodiazepines, What They Do In The Body; Online Manual
DailyMed, Official Provider Of FDA Label Information; Website
Medscape Benzodiazepine Equivalence Table; July 2018; Table
Management Of Benzodiazepine Withdrawal; Government Of South Australia; SA Health; WS2.4 Handout