The graphic below represents a continuous dialogue of Physicians in the South Florida COVID Collaborative. It is an attempt to illustrate the latest thoughts on targeted therapies in the COVID-19 disease process. It is published here with permission from the authors, who intend to modify and change it as new information becomes available and new theories are generated.
Authors: Michael Estreicher, MD and Boaz Roesenblat, MD
Illustrator: Carlos Marmolejo
References
- Yao X, Ye F, Zhang M, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020; PubMed
- Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 2020;43(3):185-188. PubMed
- Xue J, Moyer A, Peng B, Wu J, Hannafon BN, Ding W-Q (2014) Chloroquine Is a Zinc Ionophore. PLoS ONE 9(10): e109180. Full Text
- Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;:105949. PubMed
- Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; PubMed
- Cai, Qingxian; Yang, Minghui, et al. Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study. Engineering. . Full Text . Publication
- Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA. 2020; PubMed
- Wenzhong, liu; hualan, Li: COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism. ChemRxiv. Preprint. Full Text
- Wu C, Chen X, Cai Y, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020; PubMed
- Fowler AA, Truwit JD, Hite RD, et al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019;322(13):1261-1270. PubMed
- Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020; PubMed
- Xu, Xiaoling,Han, Mingfeng,Li, Tiantian,Sun, Wei,Wang, Dongsheng,Fu, Binqing,Zhou, Yonggang,Zheng, Xiaohu,Yang, Yun,Li, Xiuyong,Zhang, Xiaohua,Pan, Aijun,Wei, Haiming.(2020).Effective Treatment of Severe COVID-19 Patients with Tocilizumab. Publication
- Steven Quay, MD, PhD. COVId Hope Trial. Nebulized Heparin and N-acetyl-cysteine Protocol. Link